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姓名: 冶保献 性别: 男 出生年月: 1958, 7
最后学历: 理学博士 职称: 教 授 博士生导师
工作单位： 郑州大学化学与分子工程学院
研究方向: 生物电化学和生物电分析化学
Email: yebx@zzu.edu.cn
学 历 :
B.S. 郑州大学 1982
M.S. 郑州大学 1989
Ph.D. 武汉大学 1997
社会兼职
河南省化学会常务理事；分析化学专业委员会主任
中国仪器仪表学会分析仪器分会电化学分析专业委员会委员
荣誉称号
河南省优秀中青年骨干教师；郑州大学优秀研究生导师；河南省跨世纪学术带头人培养对象；河南省杰出青年基金获得者。
研究方向 ：
1. LB膜界面修饰与伏安传感电化学应用研究
LB膜技术可以在分子水平上制造出均匀、超薄、厚度和分子层数可控的分子组合体修饰薄膜。在这种薄膜上，修饰成分具有排列紧密有序，活性中心密度较大，电子或物质传输容易等特点；而且，LB膜较牢固，所构筑的伏安传感器具有稳定性好、响应灵敏度高、使用较长的优势。LB膜的上述特点使其在电分析化学领域取得了一定程度的进展。我们的研究是将杯芳烃、DNA、碳纳米管、石墨烯等具有特殊功能的分子（材料）利用LB膜技术构筑伏安传感器，其结合LB膜技术与功能分子材料两者的优势，解决电极界面上一些科学问题。
2. DNA分子与靶向分子相互作用的电化学研究
DNA是许多抗癌药物作用的靶分子。DNA与其靶向分子相互作用的研究在探讨生命过程机理、DNA生物传感器的研制、药物的设计与合成以及药物抗病机理的研究等方面都具有重要意义。几十年以来，人们已经从分子水平上证实：药物分子是通过插入(Intercalation)、沟槽键联(Groove binding) 或共价键联(Covalent bonding) 三种基本方式与DNA结合在一起，并经常凭借氢键（Hydrogen binding）和库仑力(Coulombic force)使相互作用加强。大多数抗癌药物通过插入或沟槽键联与DNA相互作用；与DNA共价键联的抗癌药物较少。DNA与药物分子的非共价结合相互作用主要有三种模式：（1）外源分子插入DNA分子双螺旋的碱基之间；（2）外源分子与DNA分子的带负电荷的核糖－磷酸骨架之间的静电相互作用；（3）靶向分子与DNA的大沟或小沟的碱基对边缘直接发生相互作用。我们的研究着眼于抗癌中草药与DNA相互作用的方式、方法和作用参数，研究手段以电化学技术为主。该研究为抗癌中草药的开发、抗癌机理和临床试验提供基础理论数据。
3. 生物分子电化学研究
大脑神经中枢的活动机理历来是生命科学研究的重大课题，人们一直期待着彻底揭示神经活动的奥秘，并在当前高新技术、医学、药学等领域中加以应用。近年来的研究表明，整个中枢神经系统中有多种化学物质参与和影响着人类和动物复杂的神经活动，如脑神经传导过程由神经末梢释放出化学物质并进入突触间隙。由于这些化合物直接影响人体的行为和活动，参与体内的循环和调控，并与多种功能性疾病（如精神分裂症、忧郁症等）和器质性病变（如巴金森氏综合症等）息息相关，因此，研究神经传导物质－神经递质的电子传递机理、建立快速、灵敏、可靠的检测方法，在体、实时地定量测定这类神经活动物质具有重大意义。
主持的在研和已结题科研课题
1. 1999.1- 2002.12 “ 生命信息传递过程动力学模型研究” 河南省杰出人才基金资助 编号 9924
2. 2000.1～2002.12 “生命信息传递过程的直接电化学研究” 国家教委高等学校骨干教师资助计划项目，
3. 2005.1~2007.12 “功能杯芳烃合成及在分子识别中应用的电化学研究” 国家自然科学基金资助课题， 编号：20475050。
4. 2008.1～2010.12 “杯芳烃LB膜用于伏安传感器的探索研究与应用”国家自然科学基金资助课题， 编号：20775073
5. 2013-2016 “2013.01～ 2016.12 “碳纳米管/石墨烯垂直阵列伏安传感器的设计与应用研究” 国家自然科学基金资助课题，编号：21275132
近三年发表的部分论文
2010年
1. Fei Wang, Xiaohan Wei, Chenbin Wang, Shusheng Zhang, Baoxian Ye,∗ “Langmuir–Blodgett film of p-tert-butylthiacalix[4]arene modified glassy carbon electrode as voltammetric sensor for the determination of Hg(II)” Talanta, 2010, 80, 1198–1204
2. Qiongyan Liu, Fei Wang, Yonghui Qiao, Shusheng Zhang, Baoxian Ye* “Polyaniline Langmuir–Blodgett film modified glassy carbon electrode as a voltammetric sensor for determination of Ag+ ions” Electrochimica Acta, 2010, 55, 1795–1800
3. Hongbi Zhoua, Jiying Wangb, and Baoxian Yea* “Electrochemical Investigation of Redox Reactions of Herbal Drug_Shikonin and Its Determination in Pharmaceutical Preparations”, Journal of Analytical Chemistry, 2010, 65(7), 749–754.
4. HU Kai, XU ZhanHui, ZHANG JunQiang, XIE Jing, WEN FuYong, YE BaoXian, WU YangJie & ZHANG ShuSheng* “Assisted elucidation for the retention mechanism of naphthylamine and benzenediamine on calix[4]arene stationary phase by quantum chemistry calculation method” SCIENCE CHINA Chemistry 2010, 53(4), 1–4
5. Xiaohan Wei, Fei Wang, Yumin Yin, Qiongyan Liu, Lina Zou and Baoxian Ye* “Selective detection of neurotransmitter serotonin by a gold nanoparticle-modified glassy carbon electrode” Analyst, 2010, 135, 2286–2290
6. Yanrong Wang, Shengang Xu, Tao Chen, Hongwu Guo, Qiongyan Liu, Baoxian Ye, Zhi Zhang, Zhiqun He and Shaokui Cao* “Synthesis and preliminary photovoltaic behavior study of a soluble polyimide containing ruthenium complexes” Polymer Chemistry 2010, 1(7), 1048–1055
7. Zhao, BT; Wang, CB; Wu, SJ, et al. “Synthesis and Structures of p-tert-Butylcalix[4]arene Derivatives Containing Heterocycle Functional Groups Tethered by Ether Bridges” CHINESE JOURNAL OF ORGANIC CHEMISTRY 2010, 30(8), 1212-1219
8.. Xian-Li Wu, Hong-Bi Zhou, Shu-Jie Wang and Bao-Xian Ye* “Determination of Magnesium and Calcium in Biological Samples by Potentiometric Stripping Analysis” Journal of the Chinese Chemical Society, 2010, 57(4), 647-652
9. Wei-min Shi Qi Shen Bao-xian Ye Jing-chao Tao “Quantitative structure–activity relationships study of photocytotoxicity of miscellaneous porphyrins with amino acid and uracil by gene expression programming” Medicinal Chemistry Research, 2010, 19:902–914
10. Baocheng YANG, Fei WANG, Sujuan GUO, and Baoxian YE* “Electrochemical Behavior and Voltammetric Determination of 2,4,6-Triaminopyrimidine at Glassy Carbon Electrode Modified with Multi-Walled Carbon Nanotubes/Nafion” ANALYTICAL SCIENCES, 2010, 26, 1071-1075
2011年
1. Fei Wang, Fangyuan Zhao, Yanzheng Zhang, Huige Yang, Baoxian Ye*, “Sensitive voltammetric determination of baicalein at DNA Langmuir-Blodgett film modified glassy carbon electrode” Talanta, 2011, 84(1), 160-168
2.. Sujuan Guo, Xianli Wu, Jing Zhou, Jing Wang, Baocheng Yang, Baoxian Ye* “MWNT/Nafion composite modified glassy carbon electrode as the voltammetric sensor for sensitive determination of 8-hydroxyquinoline in cosmetic” Journal of Electroanalytical Chemistry, 2011, 655, 45–49
3. Lina Zou, Xianli Wu, Yamin Li, Baocheng Yang, Shusheng Zhang, Baoxian Ye*, “Langmuir-Blodgett Film of Asymmetric Calix[4]arene Derivative Modified Electrode for Voltammetric Determination of Silver” CLEAN-SOIL AIR WATER, 2011, 39(3), 238-243
4. Lina Zou & Yamin Li & Baoxian Ye, “Voltammetric sensing of guanine and adenine using a glassy carbon electrode modified with a tetraoxocalix[2]arene[2] triazine Langmuir-Blodgett film” Microchim Acta, 2011, 173(3-4):285–291
5. Kai Hu, Wenjie Zhao, Fuyong Wen, Junwei Liu, Xiaolan Zhao, Zhanhui Xu, Bailin Niuc, Baoxian Ye, Yangjie Wu, Shusheng Zhang∗“Investigation on the preparation and chromatographic behavior of a new para-tert-butylcalix[4]arene-1,2-crown-4 stationary phase for high performance liquid chromatography” Talanta, 2011, 85, 317–324 DOI: 10.1016/j.talanta.2011.03.068
6. Wang, Fei; Xin, Changzheng; Wu, Yanju; Gao, Yumei; Ye, Baoxian， “Anodic stripping voltammetric determination of silver(I) in water using a 4-tert-butyl-1(ethoxycarbonylmethoxy)thiacalix[4]arene modified glassy carbon electrode” Journal of Analytical Chemistry, 2011, 66(1), 60-65 DOI: 10.1134/S1061934811010047
7. Lina Zou, Peili Luo, Yamin Li, Shusheng Zhang, Baoxian Ye*Sensitive and Selective Detection of Dopamine Using a DNA Immobilized Ethylenedidamine/ Polyglutamic Modified Electrode” ELECTROANALYSIS, 2011, 23(6), 1435-1441. DOI: 10.1002/elan.201000724
8. Sujuan Guo, Qianqian Zhu, Baocheng Yang, Jing Wang, Baoxian Ye* “Determination of caffeine content in tea based on poly(safranine T) electroactive film modified electrode” Food Chemistry, 2011, 129: 1311–1314 DOI: 10.1016/j.foodchem.2011.05.095
9. Fangyuan Zhao & Fei Wang &Weining Zhao & Jing Zhou & Yang Liu & Lina Zou & Baoxian Ye, “ Voltammetric sensor for caffeine based on a glassy carbon electrode modified with Nafion and graphene oxide” Microchim Acta, 2011, 174:383–390 DOI: 10.1007/s00604-011-0635-y
10. Fei Wang, Jing Zhou, Yang Liu, ShengJiang Wu, Ge Song and Baoxian Ye “Electrochemical oxidation behavior of colchicine on a graphene oxide-Nafion composite film modified glassy carbon electrode” Analyst, 2011, 136, 3943-3949 DOI: 10.1039/c1an15372b
11. Zhao, BT (Zhao Bangtun)1; Wu, SJ (Wu Shengjiang)2; Ye, BX (Ye Baoxian)2 “Synthesis and Properties of Amphiphilic Tetrathiafulvalene Derivatives” CHINESE JOURNAL OF ORGANIC CHEMISTRY , 2011, 31(7), 1027-1031
12. Wu, XL (Wu, Xian-Li)1; Luo, PL (Luo, Pei-Li)1; Zhu, SJ (Zhu, Shi-Jia)1; Zhang, SS (Zhang, Shu-Sheng)1; Ye, BX (Ye, Bao-Xian)1 “Study on the Film Properties and Recognition for Metal Ions of Calix[4]arenes Derivative by Langmuir Monolayer”, JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2011, 58(3), 362-368
2012年
1. Lina Zou, Ying Xu, Peili Luo, Shusheng Zhang and Baoxian Ye* “Electrochemical detection of dihydromyricetin using DNA immobilized ethylenedidamine/ polyglutamic modified electrode” Analyst, 2012, 137 (2), 414 – 419 DOI: 10.1039/c1an15720e
2. Fei Wang & Ying Xu & Le Wang & Kui Lu & Baoxian Ye “Immobilization of DNA on a glassy carbon electrode based on Langmuir–Blodgett technique: application to the detection of epinephrine” J Solid State Electrochem. 2012, 16:2127–2133 DOI 10.1007/s10008-011-1627-x
3.. Kai Hu, Junwei Liu, Chao Tang, Caijuan Wang, Ajuan Yu, Fuyong Wen, Wenjie Zhao, Baoxian Ye, Yangjie Wu, Shusheng Zhang. “Preparation, characterization and application of a new 25,27-bis-[2-(5-methylthiadiazole)thioethoxyl] -26,28-dihydroxy-para-tert-butyl calix[4]arenestationary phase for HPLC” J. Sep. Sci. 2012, 35, 239–247 DOI 10.1002/jssc.201100733
4. Lina Zou & Yamin Li &Wenjie Zhao & Shusheng Zhang & Baoxian Ye, “Langmuir–Blodgett film of tetraoxocalix[2]arene[2]triazine modified electrode for voltammetric determination of copper ion” J Solid State Electrochem., 2012, 16:505–511 DOI 10.1007/s10008-011-1359-y
5. Ying Xu & Fei Wang & Le Wang & Fangyuan Zhao & Baocheng Yang & Baoxian Ye “Sensitive voltammetric sensor of dihydromyricetin based on Nafion/SWNT-modified glassy carbon electrode” J Solid State Electrochem. 2012, 16:1473–1480 DOI 10.1007/s10008-011-1535-0
6. Wenjie Zhao, Kai Hu, Caijuan Wang, Song Liang, Bailin Niu∗, Lijun He, Kui Lu, Baoxian Ye, Shusheng Zhang,∗ “New oxo-bridged calix[2]arene[2]triazine stationary phase for high performance liquid chromatography” Journal of Chromatography A, 1223 (2012) 72– 78 doi:10.1016/j.chroma.2011.12.031
7. Fangyuan Zhao, Le Wang, Yanling Liu, Ge Song, Fei Wang, Baoxian Ye* “Determination of Matrine Using a New Voltammetric Sensor Based on l-Cysteine/Graphene Oxide-Chitosan Composite Film Modified Electrode” Electroanalysis 2012, 24(3), 691 – 698 DOI: 10.1002/elan.201100594
8. Jing Zhou, Kai Zhang, Jie Liu, Ge Song and Baoxian Ye* “A supersensitive sensor for rutin detection based on multi-walled carbon nanotubes and gold nanoparticles modified carbon paste electrodes” Analytical Methods, 2012, 4(5), 1350-1356 DOI: 10.1039/c2ay05930d
9. Fei Wang , Yanwei Wang , Kui Lu, Xiaohan Wei, Baoxian Ye, “Sensitive determination of methotrexate at nano-Au self-assembled monolayer modified electrode”, Journal of Electroanalytical Chemistry, 2012, 674: 83–89 doi.org/10.1016/j.jelechem.2012.04.010
10. Jing Zhou & Fei Wang & Kai Zhang & Ge Song & Jie Liu & Baoxian Ye “Electrochemical sensor for Baicalein using a carbon paste electrode doped with carbon nanotubes” Microchim Acta 2012, 178:179–186 DOI 10.1007/s00604-012-0812-7
11. Jing Zhou, Ying Xu, Le Wang, Jie Liu, Yamin Li and Baoxian Ye “Electrochemical Behavior and Voltammetric Determination of Ketamine at Pulse Plating Gold Film Modified Platinum Electrode” J. Chin. Chem. Soc. 2012, 59, 879-883 DOI: 10.1002/jccs.201100659
12. Jing Zhou, Kai Zhang, Yamin Li, Kunjing Li and Baoxian Ye* “Study on the electrochemical properties of maltol at a carbon paste electrode and its analytical application” Analytical Methods, 2012, 4(10), 3206-3211 DOI: 10.1039/c2ay25514f
13. Wang, J (Wang, Jing)1; Li, YM (Li, Yamin)1; Wu, SF (Wu, Shufang)1; Song, G (Song, Ge)1; Ye, BX (Ye, Baoxian)1 “Study on the Electrochemical Properties of Salvianic Acid A Sodium and its Analytical Application” JOURNAL OF THE CHINESE CHEMICAL SOCIETY 2012, 59(8), 947-952 DOI: 10.1002/jccs.201100757
14. Li, YM (Li, Yamin)1; Wu, SF (Wu, Shufang)1; Luo, PL (Luo, Peili)1; Liu, J (Liu, Jie)1; Song, G (Song, Ge)1; Zhang, K (Zhang, Kai)1; Ye, BX (Ye, Baoxian)1 Electrochemical Behavior and Voltammetric Determination of Theophylline at a Glassy Carbon Electrode Modified with Graphene/Nafion ANALYTICAL SCIENCES, 2012, 28(5), 497-502
15.Yang, BC (Yang, Baocheng)1; Wang, CB (Wang, Chengbin)1; Zhao, BT (Zhao, Bangtun)2; Zhang, SS (Zhang, Shusheng)1; Ye, BX (Ye, Baoxian)1 , “The electrode modified with Langmuir-Blodgett film of p-tert-butylcalix[4]arene derivatives with sulfur-containing functionalities for the determination of silver” INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY 2012, 92(15), 1776-1785 DOI: 10.1080/03067319.2010.548602
16. Luo, Peili;Liu, Jie;Li, Yamin;Miao, Yurui;Ye, Baoxian* “Voltammetric Determination of Methylparaban in Cosmetics Using a Multi-Wall Carbon Nanotubes/Nafion Composite Modified Glassy Carbon Electrode” Analytical Letters, 2012, 45(16): 2445-2454 DOI: 10.1080/00032719.2012.691589
17. Kai Zhang, Ge Song, Lingxi Yang, Jing Zhou and Baoxian Ye* “A novel self-assembly voltammetric sensor for malachite green based on ethylenediamine and graphene oxide” Anal. Methods, 2012, 4, 4257-4263 DOI: 10.1039/c2ay26039e
18. Yamin Li, Zhuo Ye, Jing Zhou, Jie Liu, Ge Song, Kai Zhang, Baoxian Ye* “A new voltammetric sensor based on poly(L-arginine)/graphene–Nafion composite film modified electrode for sensitive determination of Terbutaline sulfate” Journal of Electroanalytical Chemistry, 2012, 687, 51–57
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