噁唑、吡唑、噁二唑、噻二唑等杂环化合物的结构广泛存在于具有生物活性的天然产物和合成的药物分子当中，因此，对于这些化合物的合成一直是有机化学家研究的热点。本课题组的另一个研究方向致力于使用低毒的氧化剂、催化剂，开发绿色、高效的分子内C?X（X = C, N, O, S等）化学键的构建新方法，用于上述含氧、氮、硫等杂环化合物的合成，并建立化合物库用于生物活性（如，与蛋白相互作用、抗肿瘤、抗病毒等）筛选。
24. Lina Song, Xianhai Tian, Zhigang Lv, Ertong Li, Jie Wu, Yangxue Liu, Wenquan Yu,* Junbiao Chang.* "I2/KI-Mediated Oxidative N?N Bond Formation for the Synthesis of 1,5-Fused 1,2,4-Triazoles from N-Aryl Amidines." Journal of Organic Chemistry, 2015, 80 (14), 7219-7225.（2015影响因子：4.721）
23. Zhigang Lv, Wu He, Xianhai Tian, Jinfeng Kang, Yangxue Liu, Youmei Peng, Liyun Zheng, Qingduan Wang, Wenquan Yu,* Junbiao Chang.* "Design, Synthesis, and Biological Evaluation of New N4-Substituted 2'-Deoxy-2'-fluoro-4'-azido Cytidine Derivatives as Potent Anti-HBV Agents." European Journal of Medicinal Chemistry, 2015, 101, 103-110.（2015影响因子：3.447，药化二区）
22. Qinghua Yang, Jinfeng Kang, Liyun Zheng, Xue-Jun Wang, Na Wan, Jie Wu, Yan Qiao, Pengfei Niu, Sheng-Qi Wang, Youmei Peng, Qingduan Wang, Wenquan Yu,* Junbiao Chang.* "Synthesis and Biological Evaluation of 4-Substituted Fluoronucleoside Analogs for the Treatment of Hepatitis B Virus Infection." Journal of Medicinal Chemistry, 2015, 58 (9), 3693-3703.（2015影响因子：5.447，药化一区）
21. Pengfei Niu, Jinfeng Kang, Xianhai Tian, Lina Song, Hongxu Liu, Jie Wu, Wenquan Yu,* Junbiao Chang.* "Synthesis of 2-Amino-1,3,4-oxadiazoles and 2-Amino-1,3,4-thiadiazoles via Sequential Condensation and I2-Mediated Oxidative C–O/C–S Bond Formation." Journal of Organic Chemistry, 2015, 80 (2), 1018-1024.（2015影响因子：4.721）
20. Qinghua Yang, Xuejie Zhao, Wenquan Yu, Wu He, Xianzhen Fang, Limin Zang, Na Wan, Qingduan Wang, Liyun Zheng,* Junbiao Chang.* "Anti-hepatitis B Virus Activity of α-DDB-FNCG, a Novel Nucleoside-Biphenyldicarboxylate Compound In Vitro and In Vivo." Journal of Pharmacological Sciences, 2014, 126 (3), 208-215.（2015影响因子：2.36）
19. Xinting Zhang, Jinfeng Kang, Pengfei Niu, Jie Wu, Wenquan Yu,* Junbiao Chang.* "I2-Mediated Oxidative C?N Bond Formation for Metal-free One-pot Synthesis of Di-, Tri- and Tetra-substituted Pyrazoles from alpha,beta-Unsaturated Aldehydes/Ketones and Hydrazines." Journal of Organic Chemistry, 2014, 79 (21), 10170–10178.（2015影响因子：4.721）
18. Bingjie Liu, Yueteng Zhang, Gang Huang, Xinting Zhang, Pengfei Niu, Jie Wu, Wenquan Yu,* Junbiao Chang.* "A Concise Approach to Polysubstituted Oxazoles from N-Acyl-2-bromo Enamides via a Copper(I)/Amino Acid-catalyzed Intramolecular C–O Bond Formation." Organic & Biomolecular Chemistry, 2014, 12 (23), 3912–3923.（2015影响因子：3.562）
17. Bao-Juan Zhao, Wen-Quan Yu, Jun-Biao Chang,* Er-Tong Li, Qun-Shan Ding, Feng-Juan Li, Guang-Ying Chen, Na Wa. "Synthesis and Characterization of 3'-Deoxy-3'-fluoro-2'-O,3'-C-vinyl- ene Linked Bicyclic Uridine." Chemical Journal of Chinese Universities, 2014, 35 (1), 58–62.（2015影响因子：0.875）
16. Wenquan Yu,* Gang Huang, Yueteng Zhang, Hongxu Liu, Lihong Dong, Xuejun Yu, Yujiang Li, and Junbiao Chang.* "I2-Mediated Oxidative C–O Bond Formation for the Synthesis of 1,3,4-Oxadiazoles from Aldehydes and Hydrazides.", 2013, 78 (20), 10337–10343.（2015影响因子：4.721）
15. Chun-Hong Dong, Yue-Teng Zhang, Gang Huang, Jing-Jing Dong, Hong-Xu Liu, Xian-Hai Tian, Jing Wang, Zhi-Gang Lv, Li-Na Song, Wen-Quan Yu.* "A Solid Phase Approach to PDMP Analogs: A General Strategy for Combinatorial Library." Chinese Chemical Letters, 2013, 24 (9), 845–848.（2015影响因子：1.587）
14. Baoshan Chai, Shuyang Wang, Wenquan Yu, Huichao Li, Chuanjun Song, Ying Xu, Changling Liu,* Junbiao Chang.* "Synthesis of Novel Strobilurin-pyrimidine Derivatives and Their Antiproliferative Activity against Human Cancer Cell Lines." Bioorganic & Medicinal Chemistry Letters, 2013, 23 (12), 3505–3510.（2015影响因子：2.42）
13. Jie Wu, Wenquan Yu, Leixia Fu, Wu He, Yao Wang, Baoshan Chai, Chuanjun Song,* Junbiao Chang.* "Design, Synthesis, and Biological Evaluation of New 2'-Deoxy-2'-fluoro-4'-triazole Cytidine Nucleosides as Potent Antiviral Agents." European Journal of Medicinal Chemistry, 2013, 63, 739–745.（2015影响因子：3.447，药化二区）
12. Li-Yun Zheng, Li-Min Zang, Qing-Hua Yang, Wen-Quan Yu, Xian-Zhen Fang, Yu-Hai Zhang, Xue-Jie Zhao, Na Wan, Yue-Teng Zhang, Qing-Duan Wang, Jun-Biao Chang.* "Anti-hepatitis B Virus Activity of α-DDB-DU, A Novel Nucleoside Analogue, In Vitro and In Vivo." European Journal of Pharmacology, 2013, 702 (1–3), 258–263.（2015影响因子：2.532）
11. Jinhong Chang,* Travis K. Warren, Xuesen Zhao, Tina Gill, Fang Guo, Lijuan Wang, Mary Ann Comunale, Yanming Du, Dominic S. Alonzi, Wenquan Yu, Hong Ye, Fei Liu, Ju-Tao Guo, Anand Mehta, Andrea Cuconati, Terry D. Butters, Sina Bavari, Xiaodong Xu, Timothy M. Block. "Small Molecule Inhibitors of ER α-Glucosidases are Active against Multiple Hemorrhagic Fever Viruses." Antiviral Research, 2013, 98 (3), 432–440.（影响因子：3.925）
10. Andrea Cuconati,* Courtney Mills, Cally Goddard, Xianchao Zhang, Wenquan Yu, Haitao Guo, Xiaodong Xu, Timothy M. Block.* "Suppression of AKT Anti-Apoptotic Signaling by a Novel Drug Candidate Results in Growth Arrest and Apoptosis of Hepatocellular Carcinoma Cells." PLoS ONE, 2013, 8 (1), e54595.（影响因子：3.73）
9.Dawei Cai, Courtney Mills, Wenquan Yu, Ran Yan, Carol E. Aldrich, Jeffry R. Saputelli, William S. Mason, Xiaodong Xu, Ju-Tao Guo, Timothy M. Block, Andrea Cuconati,* Haitao Guo.* "Identification of the Disubstituted Sulfonamide Compounds as Specific Inhibitors of Hepatitis B Virus Covalently Closed Circular DNA Formation." Antimicrobial Agents and Chemotherapy, 2012, 56 (8), 4277–4288.（影响因子：4.565）
8.Wenquan Yu, Tina Gill, Lijuan Wang, Yanming Du, Hong Ye, Xiaowang Qu, Ju-Tao Guo, Andrea Cuconati, Kang Zhao, Timothy M. Block, Xiaodong Xu,* Jinhong Chang.* "Design, Synthesis, and Biological Evaluation of N-Alkylated Deoxynojirimycin (DNJ) Derivatives for the Treatment of Dengue Virus Infection." Journal of Medicinal Chemistry, 2012, 55 (13), 6061–6075.（2015影响因子：5.447，药化一区）
7.Wenquan Yu, Cally Goddard, Elizabeth Clearfield, Courtney Mills, Tong Xiao, Haitao Guo, John D. Morrey, Neil E. Motter, Kang Zhao, Timothy M. Block, Andrea Cuconati,* Xiaodong Xu.* "Design, Synthesis, and Biological Evaluation of Triazolo-pyrimidine Derivatives as Novel Inhibitors of Hepatitis B Virus Surface Antigen (HBsAg) Secretion." Journal of Medicinal Chemistry, 2011, 54 (16), 5660–5670.（2015影响因子：5.447，药化一区）
6.Xiaowang Qu, Xiaoben Pan, Jessica Weidner, Wenquan Yu, Dominic Alonzi, Xiaodong Xu, Terry Butters, Timothy Block, Ju-Tao Guo, Jinhong Chang.* "Inhibitors of Endoplasmic Reticulum α-Glucosidases Potently Suppress Hepatitis C Virus Virion Assembly and Release." Antimicrobial Agents and Chemotherapy, 2011, 55 (3), 1036–1044.（影响因子：4.565）
5.Jinhong Chang,* Wouter Schul, Terry D. Butters, Andy Yip, Boping Liu, Anne Goh, Suresh B. Lakshminarayana, Dominic Alonzi, Gabriele Reinkensmeier, Xiaoben Pan, Xiaowang Qu, Jessica M. Weidner, Lijuan Wang, Wenquan Yu, Nigel Borune, Mark A. Kinch, Jamie E. Rayahin, Robert Moriarty, Xiaodong Xu, Pei-Yong Shi, Ju-Tao Guo, Timothy M. Block. "Combination of α-Glucosidase Inhibitor and Ribavirin for the Treatment of Dengue Virus Infection In Vitro and In Vivo." Antiviral Research, 2011, 89 (1), 26–34.（影响因子：3.925）
4.Chunxiao Xu, Haitao Guo, Xiao-Ben Pan, Richeng Mao, Wenquan Yu, Xiaodong Xu, Lai Wei, Jinhong Chang, Timothy M. Block, Ju-Tao Guo.* "Interferons Accelerate the Decay of Replication-competent Nucleocapsids of Hepatitis B Virus." Journal of Virology, 2010, 84 (18), 9332–9340.（影响因子：5.076）
3.Yan Chen, Tong Ju, Junwei Wang, Wenquan Yu, Yunfei Du,* Kang Zhao.* "Concurrent α-Iodination and N-Arylation of Cyclic β-Enaminones." Synlett, 2010 (2), 231–234.（影响因子：2.655）
2.Wenquan Yu, Yunfei Du, Kang Zhao.* "PIDA-Mediated Oxidative C-C Bond Formation: Novel Synthesis of Indoles from N-Aryl Enamines." Organic Letters, 2009, 11 (11), 2417–2420.（2015影响因子：6.364）
1.Jing Wei, Wen-Quan Yu, Qing-Zhi Gao.* "Advances in the Study of A2B Adenosine Receptor Antagonists." Acta Pharmaceutica Sinica, 2008, 43 (3), 241–246.（影响因子：1.085）
3.Wenquan Yu. "Design, Synthesis, and Biological Evaluation of Triazolo-pyrimidine Derivatives as Novel Inhibitors of Hepatitis B Virus Surface Antigen (HBsAg) Secretion." 8th Sino-US Chemistry Professors Conference. Jul. 2012, Kunming, China.
2.Wenquan Yu, et al. "Design, Synthesis and Biological Evaluation of N-Alkylated DNJ Derivatives for the Treatment of Dengue Virus (DENV) Infection." Gordon Research Conference: High Throughput Chemistry & Chemical Biology. Jun. 2011, New Hampshire, USA.
1.Wenquan Yu, et al. "Synthesis and Biological Evaluation of Triazolo-Pyrimidine Derivatives as Novel Inhibitors of Hepatitis B Virus Surface Antigen (HBsAg) Secretion." 23rd International Conference on Antiviral Research, Apr. 2010, San Francisco, USA. (Antiviral Research, 2010, 86, A42)