【李占先】郑州大学化学与分子工程学院研究生导师介绍

信息发布

　　李占先，博士，副教授，硕士生导师。

　　2001年7月毕业于郑州大学化学系，2006年5月获得中科院理化所博士学位，2006年7月进入北京大学化学与分子工程学院进行博士后研究工作，2008年7月进入郑州大学化学系工作。

　　联系方式：电子邮件：lizx@zzu.edu.cn

　　个人网址：http://teachers.zzu.edu.cn/Teacher/personal/zxli

　　实验室：化学实验楼121

　　通讯地址：郑州大学化学与分子工程学院 450001

　　研究方向：

　　生物荧光分子探针的合成及荧其光成像方面的应用；

　　有机-无机/高分子复合材料在生物荧光成像方面的应用。

　　学习及工作经历

　　1997-2001年，郑州大学化学系，学士学位；

　　2001-2006年，中科院理化技术研究所，博士学位；

　　2006-2008年，北京大学，稀土材料化学及应用国家重点实验室，博士后。

　　在研项目

　　能量转移型肼的上转换纳米复合比率荧光探针的制备及荧光成像（U1504203），国家自然基金委，省联合基金，主持

　　细胞器靶向近红外比率荧光探针的设计、合成及应用，中科院开放课题，主持

　　树枝状高分子的荧光离子检测研究，2011高校博士点新教师联合项目（编号20114101120003），主持

　　多异氰酸酯与硅氧烷及酚醛树脂反应特性研究，横向项目，主持

　　ZD-121聚氨酯密封胶的研制（水性聚氨酯涂料的研制），横向项目，主持

　　废旧材料的回收利用及新材料的研制，开发，横向项目，主持

　　近期代表文章:

　　Zhang, W.; Liu, X.; Zhang, H.; Feng, C.; Liu, C.; Yu, M.*; Wei, L. and Li, Z.* A fluorescent probe for benzenethiols and its application on test paper, in water samples and living cells, J. Mater. Chem. C, 2015, 3, 8248--8254.

　　Liu, C. X.; Shi, C. X.; Li, H. X.; Du, W. W.; Li, Z. X.*; Wei, L. H.; Yu, M. M.* Nanomolar fluorescent quantitative detection of formaldehyde with a 8-hydroxyquinoline derivative in aqueous solution and electrospun nanofibers. Sens. Actuators B, 2015, 219, 185–191.

　　Li, Z. X.*; Zhang, W. Y.; Liu, X. J.; Liu, C. X.; Yu, M. M.*; Wei L. H.* Naked-eye-based selective detection of pyrophosphate with Zn2+ complex in aqueous solution and electrospun nanofibers. RSC Adv., 2015, 5, 25229–25235.

　　Liu, C. X.; Xu, J.; Yang, F.; Zhou, W.; Li, Z. X.*; Wei L. H.; Yu, M. M.* Nanomolar Cu2+ and F– naked-eye detection with a 1,8-naphthalimide-based colorimetric probe. Sens. Actuators B, 2015, 212, 364–370.

　　Du, W. W.; Xu, J.; Li, H. X.; Feng, C. C.; Yu, M. M.*; Li Z. X.*; Wei L. H. Naked-eye and fluorescent detection of basic pH and F? with a 1,8-naphthalimide-based multifunctional probe. RSC Adv., 2015, 5, 15077–15083.

　　Zhou, W.; Dong, H.; Yan, H.; Shi, C. X.; Yu, M. M.*; Wei, L. H.; Li, Z. X.* HCHO-reactive molecule with dual-emission-enhancement property for quantitatively detecting HCHO in near 100% water solution. Sens. Actuators B, 2015, 209, 664–669.

　　Liu, X. J.; Zhang, W.Y.; Li, C. X.; Zhou, W.; Li, Z. X.*; Yu, M. M.*; Wei, L. H. Nanomolar detection of Hcy, GSH and Cys in aqueous solution, test paper and living cells. RSC Adv., 2015, 5, 4941–4946.

　　Li, Z. X.*; Liu, X. J.; Zhao, W. Y.; Wang, S.; Zhou, W.; Wei, L. H.; Yu, M. M.* Naked-eye detection of C1–C4 alcohols based on ground-state intramolecular proton transfer. Anal. Chem., 2014, 86, 2521?2525.

　　Liu, X. J.; Chen, M. X.; Liu, Z. P.; Yu, M. M.*; Wei, L. H.; Li, Z. X.* Synthesis of 1,8-naphthyridine and BF2-based isomers and their application in fluorogenic sensing Cd2+. Tetrahedron, 2014, 70, 658?663.

　　Li, H. Q.; Li, Z. X.*; Wu, L. Z.; Zhang, Y. N.; Yu, M. M.*; Wei, L. H.* Constructing metal nanoparticle multilayers with polyphenylenedendrimer/gold nanoparticles via “Click” chemistry. Langmuir, 2013, 29, 3943?3949.

　　Yu, M. M.*; Yuan, R. L.; Shi, C. X.; Zhou, W.; Wei, L. H.; Li, Z. X.* 1,8-Naphthyridine and 8-hydroxyquinoline modified rhodamine B derivatives: “Turn-on” fluorescent and colorimetric sensors for Al3+ and Cu2+. Dyes Pigm., 2013, 99, 887?894.

　　Li, X. Y.; Yu, M. M.; Yang, F. l.; Liu, X. J.; Wei, L. H.; Li, Z. X.* A dual-model and on–off fluorescent Al3+/Cu2+-chemosensor and the detection of F-/Al3+ with 'in situ’ prepared Al3+/Cu2+ complexes. New J. Chem., 2013, 37, 2257?2260.

　　Li, Z. X.*; Zhou, W.; Zhang, L. F.; Yuan, R. L.; Liu, X. J.; Wei, L. H.; Yu, M. M.* Highly selective ratiometric fluorescent detection of Fe3+ with a polyphenyl derivative. J. Lumin., 2013, 136, 141–144.

　　Li, Z. X.*; Zhao, W. Y.; Li, X. Y.; Zhu, Y. Y.; Liu, C. M.; Wang, L. N.; Yu, M. M.*; Wei, L. H.; Tang, M. S.; Zhang, H. Y.* 1,8-Naphthyridine-derived Ni2+/Cu2+-selective fluorescent chemosensor with different charge transfer processes. Inorg. Chem., 2012, 51, 12444?12449.

　　Li, Z. X.*; Zhang, L. F.; Li, X. Y.; Guo, Y. K.; Ni, Z. H.; Chen, J. H.; Wei, L. H.; Yu, M. M.* A Fluorescent color/intensity changed chemosensor for Fe3+ by photo-induced electron transfer (PET) inhibition of fluoranthene derivative. Dyes Pigm., 2012, 94, 60–65.

　　Wang, L. N.; Yu, M. M.*; Liu, Z. T.; Zhao, W. Y.; Li, Z. X.*; Ni, Z. H.; Li, C. C.; Wei, L. H.* A visible light excitable ‘‘On–Off’’ and ‘‘Green–Red’’ fluorescent chemodosimeter for Ni2+/Pb2+. New J. Chem., 2012, 36, 2176–2179.

　　Zhou, Y., Li, Z. X.; Zang, S. Q.*; Zhu, Y. Y.; Zhang, H. Y.*; Hou, H. W.; Mak, T. C. W. A Novel sensitive turn-on fluorescent Zn2+ chemosensor based on an easy to prepare C-3-symmetric schiff-base derivative in 100% aqueous solution. Org. Lett., 2012, 14, 1214–1217.

　　Li, H. Q.; Li, Z. X.; Wu, L. Z.; Liu, F.; Zhou, J.; Luan, M.; Yu, M. M.*; Wei, L. H.* Water-soluble starlike poly(acrylic acid) graft polymer: preparation and application as templates for silver nanoclusters. Polym. Bull., 2012, 68, 2229–2242.

　　Zhanxian Li, Wanying Zhao, Yuna Zhang, Lifeng Zhang, Mingming Yu*, Jinxia Liu* and Hongyan Zhang* An “off-on” fluorescent chemosensor of selectivity to Cr3+ and its application to MCF-7 cells Tetrahedron, 2011, 67, 7096?7100.

　　Zhanxian Li, Lifeng Zhang, Lina Wang, Yongkai Guo, Lianheng Cai, Mingming Yu, Liuhe Wei Highly Sensitive and Selective Fluorescent Sensor for Zn2+/Cu2+ and New Approach for Sensing Cu2+ by Central Metal Displacement Chem. Commun., 2011, 47, 5798?5800.

　　Zhanxian Li, Mingming Yu, Lifeng Zhang, Ming Yu, Jinxia Liu, Liuhe Wei, and Hongyan Zhang A “switching on” fluorescent chemodosimeter of selectivity to Zn2and its application to MCF-7 cells Chem. Commun., 2010, 46, 7169?7171.

　　Zhang, Chao; Zhou, Huan-Ping; Liao, Long-Yan; Feng, Wei; Sun, Wei; Li, Zhan-Xian; Xu, Chun-Hu; Fang, Chen-Jie; Sun, Ling-Dong; Zhang, Ya-Wen; Yan, Chun-Hua. Luminescence modulation of ordered upconversion nanopatterns by a photochromic diarylethene: rewritable optical storage with nondestructive readout Adv. Mater., 2010, 22(5), 633?637.

　　Wei Sun, Can Zhou, Chun-Hu Xu, Yi-Qun Zhang, Zhan-Xian Li, Chen-Jie Fang, Ling-Dong Sun and Chun-Hua Yan Intramolecular Charge Transfer in 5-Methoxy-2-(2-pyridyl)thiazole-Derived Fluorescent Molecules with Different Acceptor or Donor Substituents J. Phys. Chem. A, 2009, 113 (30), 8635–8646.

　　Zhanxian Li, Chunhu Xu, Wei Sun, Yanchun Bai, Chao Zhang, Chenjie Fang, and Chunhua Yan, “Solvent-Sensitive Charge-Transfer Absorption Behaviours and Dual-Emissive Fluoresc -ent Property of a Thiazole-Conjugated Pyridinium Complex”, New J. Chem., 2009, 113, 853?859.

　　Zhanxian Li, Longyan Liao, Wei Sun, Chunhu, Xu, Chao Zhang, Chenjie Fang, and Chun huaYan, “Reconfigurable Cascade Circuit in a Photo- and Chemical-Switchable Fluorescent Diarylethene Derivative”, J. Phys. Chem. C., 2008, 112,5190–5196.

　　Zhanxian Li, Wei Sun, Yanfeng Yue, Minghua Zheng, Chunhu Xu, Jingyi Jin, Chenjie Fang, and Chunhua Yan, “Synthesis of a Solvent-sensitive Highly Fluorescent Derivative of Perflu orocy-Clopentene”, Tetrahedron Lett., 2007, 48, 7675–7679.

　　Zhimin Wang, Zhanxian Li, Zhaohui Liu, "photostimulated reversible attachment of gold nanoparticles on multi-walled carbon nanotubes", J. Phys. Chem. C.,2009, 113,3899–3902.

　　Mingming Yu, Zhanxian Li, Liuhe Wei, Donghui Wei, Mingsheng Tang, “A 1,8-Naphthyrid ine-based Fluorescent Chemodosimeter for the Rapid Detection of Zn2 and Cu2 ”, Org. Lett., 2008, 10, 5115–5118.

　　Zhanxian Li, Wenfu Fu, Mingming Yu,Xijuan Zhao,and Yong Chen, “The Synthesis and Properties of Phenolic Schiff bases based on 1,8-naphthyridine”, Dyes Pigm., 2007, 75, 516–520.

　　授权专利

　　一种低级醇检测探针、制备方法及应用。国家专利，专利号：ZL201310198342.4，第一名

　　一种检测细胞内锌离子的分子荧光开关及其应用。国家专利，专利号：ZL201010181802.9，第一名

　　萘联苯衍生物金属离子荧光探针及其应用。国家专利，专利号：ZL201110169892.4，第一名