【刘红涛】郑州大学生命科学学院研究生导师介绍

信息发布

　　刘红涛，副教授，硕士生导师。主要从事肿瘤基因治疗研究，目前在国内外期刊上发表论文50余篇，其中SCI收录15篇，目前主持国家自然科学基金项目2项，参与了河南省医学科技攻关项目、多项国家自然科学基金及省部级项目的研究工作。并作为Molecular Biology Reports，Tumor Biology等杂志的审稿专家。

　　1、教育和研究工作经历

　　1996. 9-2000. 7，华中师范大学，生命科学学院，本科/学士

　　2000. 9-2003. 7，华中师范大学，生命科学学院，硕士

　　2001. 7-2002. 6，中科院病毒所，从事藻病毒的分离和分子生物学研究

　　2003. 7-2008. 6，郑州大学医学实验中心，从事杜氏盐藻生物反应器的研究

　　2008. 7至今，郑州大学生物工程系，从事肿瘤基因治疗研究

　　2、主持项目

　　国家自然科学基金项目：杜氏盐藻异养工程藻株的建立（No. 30600006）[2007. 1-2009. 12]（主持）

　　国家自然科学基金项目：食管鳞癌中藻蓝蛋白受体的分离和鉴定及其在食管鳞癌中的功能（No. 81272691） [2013. 1-2013. 12] （主持）

　　河南省医学科技攻关项目：Notch1信号转导途径在食管癌发生发展中的作用及调控机制的研究（No. 20050009）[2005. 1-2006. 12]（项目主要参与者）

　　3、科研成果

　　[1] Wang F, Wang LX, Li SL, Li K, He W, Liu HT#, Fan QX. Downregulation of stathmin is involved in malignant phenotype reversion and cell apoptosis in esophageal squamous cell carcinoma. J Surg Oncol, 2011, 103(7): 704-715 (#Corresponding author)

　　[2] Liu HT, Wang N, Wang X, Li SL. Overexpression of Pim-1 is associated with poor prognosis in patients with esophageal squamous cell carcinoma [J]. J Surg Oncol, 2010, 102 (6): 683-688.

　　[3] Li S, Xi Y, Zhang H, Wang Y, Wang X, Liu H#, Chen K. A pivotal role for Pim-1 kinase in esophageal squamous cell carcinoma involving cell apoptosis induced by reducing Akt phosphorylation [J]. Oncol Rep, 2010, 24 (4): 997-1004. (#Corresponding author)

　　[4] Xu Z, Liu H, Lv X, Liu Y, Li S, Li H. Knockdown of the Bmi-1 oncogene inhibits cell proliferation and induces cell apoptosis and is involved in the decrease of Akt phosphorylation in the human breast carcinoma cell line MCF-7 [J]. Oncol Rep, 2011, 25 (2): 409-418.

　　[5] Wang X, Liu HT, Li S, Li K, Lin N, Fan QX, Zheng YL. Prognostic value of protease-activated receptor 2 expression in oesophageal squamous cell carcinoma [J]. J Int Med Res, 2010, 38 (4): 1381-1388.

　　[6] Lu ZM, Liu HT, Xue LX, Xu PR, Gong TX, Hou GQ. An activated Notch1 signaling pathway inhibits cell proliferation and induces apoptosis in human esophageal squamous cell carcinoma cell line EC9706 [J]. Int J Oncol, 2008, 32 (3): 643-651.

　　[7] Wang W, Xue LX, Liu HT, Wang PJ, Xu PR, Cai YR. Aberrant Changes of Wnt2/beta-Catenin Signaling Pathway Induced by Sodium Nitroprusside in Human Esophageal Squamous Cell Carcinoma Cell Lines [J]. Cancer Invest, 2010, 28 (3): 230-241.

　　[8] Jia YL, Xue LX, Liu HT, Li J. Characterization of the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene from the halotolerant alga Dunaliella salina and inhibition of its expression by RNAi [J]. Curr Microbiol, 2009, 58 (5): 426-431.

　　[9] Feng SY, Xue LX, Liu HT, Lu PJ.Improvement of efficiency of genetic transformation for Dunaliella salina by glass beads method [J]. Mol Biol Rep, 2009, 36 (6): 1433-1439.

　　[10] Jia Y, Xue L, Li J, Liu H. Isolation and proteomic analysis of the halotolerant alga Dunaliella salina flagella using shotgun strategy [J]. Mol Biol Rep, 2010, 37 (2): 711-716.

　　[11] Cui LQ, Chai YR, Li J, Liu HT, Zhang L, Xue LX. Identification of a glucose-6-phosphate isomerase involved in adaptation to salt stress of Dunaliella salina [J]. J Appl Phycol, 2010, 22 (5): 563-568.

　　[12] Fan TL, Jiang GZ, Suo ZH, Liu HT, Xu PR, Ji ZY, Zhang LR, Yang GR.Down-regulation of the apoptosis-inducing factor or Bcl-2 inhibitor of transcription by RNA interference can alleviate TAp63gamma-induced apoptosis in esophageal squamous carcinoma EC9706 cells [J]. Int J Oncol, 2009, 35 (2): 359-367.

　　[13] Jiao J, Qin ZB, Li S, Liu HT, Lu ZM. Potential role of Notch1 signaling pathway in laryngeal squamous cell carcinoma cell line Hep-2 involving proliferation inhibition, cell cycle arrest, cell apoptosis, and cell migration [J]. Oncol Rep, 2009, 22 (4): 815-823.

　　[14] Li J, Xue LX, Yan HX, Liu HT, Liang JY. Inducible EGFP expression under the control of the nitrate reductase gene promoter in transgenic Dunaliella salina [J]. J App Phycol, 2008, 20 (2): 137-145.

　　[15] Tian F, Zang WD, Hou WH, Liu HT, Xue LX. Nuclear factor-kB signaling pathway constitutively activated in esophageal squamous cell carcinoma cell lines and inhibition of growth of cells by small interfering RNA [J]. Acta Biochim Biophys Sin (Shanghai), 2006, 38 (5): 318-326.

　　[16] 郜辉, 冯应勤, 朱金峰, 何兴端, 鲁培, 刘红涛#. 抑制酰基-辅酶A去饱和酶1表达对食管鳞癌细胞增殖和凋亡的影响及其分子机制探讨 [J]. 肿瘤, 2012, 32 (9): 681-688. （#通讯作者）

　　[17] 陈涛, 刘红涛#, 吕朋举, 薛乐勋. 杜氏盐藻异养表达载体的构建及异养转化株的鉴定 [J]. 生物工程学报, 2009, 25 (3): 392-398. （#通讯作者）