朱志兀教授——郑州大学化学与分子工程学院博士生导师

郑大考研网

朱志兀， 1963年出生于江苏常州，河南省特聘教授、博士生导师。1993年毕业于美国威斯康新大学密尔沃基分校获化学博士学位，1993-1997年在美国密西根大学医学院Dennis Thiele教授的实验室从事基因调控的博士后研究， 1997－2006年就职美国加里弗尼亚大学Santa Cruz分校Assistant教授。
    2006年就职郑州大学化学系特聘教授，在郑州大学化学系建立了分子生物学和新药研发实验室，并与郑州大学合作建立了中美合资高新技术企业——郑州泰基鸿诺药物科技有限公司，进行“产学研”模式的研究开发。主持、合作完成美国国家自然科学基金、美国国家卫生院James A. Shannon Director奖励基金等美国基金项目6项；回国后在研国家自然科学基金、河南省重大科技攻关计划项目和河南省基础与前沿技术研究计划项目。在Cell、J. Biol. Chem.、Biochemistry、Yeast、Brain Research等国际著名期刊上发表学术论文20多篇。
    目前主要从事与重金属离子铜和铁相关基因调控、重金属离子诱导神经退化机理、细胞周期调控营养元素稳态相关的信号转导机理研究；细胞抗热激、抗氧化相关基因的研究等。实验室的另一主要研究方向是鉴定有重要生物活性的天然有机小分子化合物以及与生物分子靶点作用机理的研究。

代表论文：
Kaushik Ghosh, Alisha Thompson, Eric Oh, Xiaoli Shi, Robert A. Goldbeck, Zhu Zhiwu, Chris Vulpe, and Theodore R. Holman (2005) Spectroscopic and Biochemical Characterization of Binding of Heme to Yeast Dap1p and Mouse PGRMC1p .  Biochemistry 44, 16729-16736.

Shi, X., Stoj, C., Romeo, A., Kosman, D. J. and Zhu, Z. (2003) Fre1p Cu2+ Reduction and Fet3p Cu1+ Oxidation Modulate Copper Toxicity in Saccharomyces cerevisiae. J. Biol. Chem. 278, 50309-50315.

Shi, X., Chabarek, K., Budai, A. and Zhu, Z. (2003) Iron Requirement for GAL Gene Induction in the Yeast Saccharomyces cerevisiae. J. Biol. Chem. 278, 43110-43113.  

Kwik-Uribe, Catherine L.; Reaney, Stephen; Zhu, Zhiwu; Smith, Donald*  (2003) Alterations in cellular IRP-dependent iron regulation by in vitro manganese exposure in undifferentiated PC12 cells; Brain Research; 1, 1-15.

Yonkovich, J, McKenndry, R., Shi. X. and Zhu, Z. (2002) Copper ion-sensing transcription factor Mac1p post-translationally controls the degradation of its target gene product Ctr1p.  J. Biol. Chem. 277, 23981-23984.

Zhu, Z., Heredia, J. and Teves, R. (2002) Sensory protein modification: A new feature in copper balancing, in Handbook of copper pharmacology and toxicology, ed. E. J. Massaro, Human Press, Totowa, NJ, pp.475-480.

Heredia, J., Crooks, M, and Zhu, Z. (2001) Phosphorylation and Cu+-coordination dependent DNA-binding of the transcription factor Mac1 in the regulation of copper transport.  J. Biol. Chem. 276, 8793-8797.
Zhu, Z., McKendry, R. and Chavez, C. L. (2000) Signaling in Copper Ion Homeostasis.  In Cell and Molecular Responses to Stress, vol. 1, Kenneth B. Storey and Janet M. Storey ed.  JAI Press, Stamford, CT.

Zhu, Z., Simon, L., Pena, M. O. and Thiele, D. J. (1998) Copper differentially regulates the activity and degradation of yeast Mac1 transcription factor.  J. Biol. Chem. 273,1277-1280.

Simon, L., Zhu, Z. and Thiele, D. J. (1997) Copper-specific transcriptional repression of yeast genes encoding critical components in the copper transport pathway.  J. Biol. Chem. 272,15951-15958.

Szczypka, M. S., Zhu, Z., Silar, P. and Thiele, D. J. (1997) Saccharomyces cerevisiae Mutants Altered in Vacuole Function Are Defective in Copper Detoxification and
Iron-Responsive Gene Transcription. Yeast 13, 1423-1435.

Zhu, Z. and Thiele, D. J. (1996) A specialized nucleosome modulates transcription factor access to a C. glabrata metal responsive promoter.  Cell 87, 459-470.

Zhu, Z. and Thiele, D. J. (1996) Toxic metal-responsive gene transcription.  In Stress-Inducible Cellular Responses.  Feige, U., Morimoto, R. I., Yahara, I. and Polla, B. S. (ed), Birkhauser Verlag, Basel, Switzerland.

Zhu, Z., Petering, D. H. and Shaw III, C. F. (1995) Electrostatic influences on the kinetics of the reactions of lobster metallothioneins with the electrophilic disulfides 2,2’-dithiodipyridine (PySSPy) and       5,5’-dithiobis (2-nitrobenzoic acid) (ESSE).  Inorg. Chem. 34, 4477-4483.

Zhu, Z., DeRose, E. F., Petering, D. H. and Shaw III, C. F. (1994) Sequential proton resonance assignments and metal cluster topology of lobster metallothionein-1.  Biochemistry 33, 8858-8865.

Zhu, Z., Szczypka, M. S. and Thiele, D. J. (1993) Transcriptional regulation and function of yeast metallothionein.  In Genetics Response to Metals  ed. Sarkar, B., Marcel Dekker, Inc., New York, NY.

Zhu, Z., Goodrich, M., Isab, A. A. and Shaw III, C. F. (1992) Biphasic reactions of DTNB with lobster Cd6- and Cd5Cu-metallothionein-2 which have two type-B (M3S9) clusters.  Inorg. Chem. 31,1662-1667.